Adding a new agent to G-CSF, Aphexda (motixafortide), makes treatment even more beneficial, as both drugs worked to collect more stem cells in a shorter period of time compared to GC-SF alone. The new advancement of G-CSF (granulocyte-colony stimulating factor), a factor that duplicates the production of white cells, which pushes negative stem cells out of the body. Mobilization is the phrase (where we) will encourage those stem cells to leave the bone marrow so that they can circulate in the blood and we can collect them off a machine called an apheresis machine, which functions much like dialysis like machine,” explained Mikhael. And to do that, we've tried over many, many years different types of therapies for mobilization. “We collect a patient's stem cells and then give them high dose chemotherapy then restore their stem cells to grow a new marrow because that chemotherapy not only affects the myeloma but affects their own inherent marrow. Joseph Mikhael, professor in the Applied Cancer Research and Drug Discovery Division at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope Cancer Center, and is also the Chief Medical Officer of the International Myeloma Foundation. A stem cell transplant is one of the most efficient tools to treat multiple myeloma, a cancer that originates in the plasma that builds up within the bone marrow, according to expert Dr.
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